Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS dis...
Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Positive and negative allosteric modulators (PAMs and NAMs) have now been identified for members of each major subfamily of G protein-coupled receptors (GPCRs). Multiple allosteric modulators have been optimized to have drug-like properties, and several allosteric modulators of class A and class C GPCRs are now advancing in preclinica...
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Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4208620
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4208620
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ISSN
1474-1776
E-ISSN
1474-1784
DOI
10.1038/nrd4308
