Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
How stage-specific enhancer dynamics modulate gene expression patterns essential for organ development, homeostasis and disease is not well understood. Here, we addressed this question by mapping chromatin occupancy of GATA4—a master cardiac transcription factor—in heart development and disease. We find that GATA4 binds and participates in establis...
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Full title
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4236193
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4236193
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms5907
