Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Polyglutamine repeat expansion in ataxin-3 causes neurodegeneration in the most common dominant ataxia, spinocerebellar ataxia type 3 (SCA3). Since reducing levels of disease proteins improves pathology in animals, we investigated how ataxin-3 is degraded. Here we show that, unlike most proteins, ataxin-3 turnover does not require its ubiquitinatio...
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Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4237202
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4237202
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms5638
