PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumor...
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
About this item
Full title
Author / Creator
Lee, William , Teckie, Sewit , Wiesner, Thomas , Ran, Leili , Prieto Granada, Carlos N , Lin, Mingyan , Zhu, Sinan , Cao, Zhen , Liang, Yupu , Sboner, Andrea , Tap, William D , Fletcher, Jonathan A , Huberman, Kety H , Qin, Li-Xuan , Viale, Agnes , Singer, Samuel , Zheng, Deyou , Berger, Michael F , Chen, Yu , Antonescu, Cristina R and Chi, Ping
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Ping Chi and colleagues identify recurrent inactivating mutations in the PRC2 core components
EED
and
SUZ12
in malignant peripheral nerve sheath tumors. They further show that PRC2 loss is associated with loss of H3K27 trimethylation and aberrant expression of PRC2 target genes and downstream pathways.
Malignant peripheral nerve shea...
Alternative Titles
Full title
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
Authors, Artists and Contributors
Author / Creator
Teckie, Sewit
Wiesner, Thomas
Ran, Leili
Prieto Granada, Carlos N
Lin, Mingyan
Zhu, Sinan
Cao, Zhen
Liang, Yupu
Sboner, Andrea
Tap, William D
Fletcher, Jonathan A
Huberman, Kety H
Qin, Li-Xuan
Viale, Agnes
Singer, Samuel
Zheng, Deyou
Berger, Michael F
Chen, Yu
Antonescu, Cristina R
Chi, Ping
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4249650
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4249650
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3095
