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AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers

AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4254172

AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers

About this item

Full title

AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers

Publisher

United States: Elsevier B.V

Journal title

Molecular oncology, 2014-12, Vol.8 (8), p.1419-1428

Language

English

Formats

Publication information

Publisher

United States: Elsevier B.V

More information

Scope and Contents

Contents

Aurora kinase A is a frequently amplified and overexpressed gene in upper gastrointestinal adenocarcinomas (UGCs). Using in vitro cell models of UGCs, we investigated whether AURKA can regulate Signal Transducer and Activator of Transcription 3 (STAT3). Our data indicate that overexpression of AURKA in FLO-1 and AGS cells increase STAT3 phosphoryla...

Alternative Titles

Full title

AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4254172

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4254172

Other Identifiers

ISSN

1574-7891

E-ISSN

1878-0261

DOI

10.1016/j.molonc.2014.05.012

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