Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis
Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis
About this item
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Author / Creator
Noda, Shinji , Asano, Yoshihide , Nishimura, Satoshi , Taniguchi, Takashi , Fujiu, Katsuhito , Manabe, Ichiro , Nakamura, Kouki , Yamashita, Takashi , Saigusa, Ryosuke , Akamata, Kaname , Takahashi, Takehiro , Ichimura, Yohei , Toyama, Tetsuo , Tsuruta, Daisuke , Trojanowska, Maria , Nagai, Ryozo and Sato, Shinichi
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Systemic sclerosis (SSc) is manifested by fibrosis, vasculopathy and immune dysregulation. So far, a unifying hypothesis underpinning these pathological events remains unknown. Given that SSc is a multifactorial disease caused by both genetic and environmental factors, we focus on the two transcription factors, which modulate the fibrotic reaction...
Alternative Titles
Full title
Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4268882
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4268882
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms6797
