Detecting ultralow-frequency mutations by Duplex Sequencing
Detecting ultralow-frequency mutations by Duplex Sequencing
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The high error rate of NGS methods has limited the ability to accurately detect ultra-low-frequency mutations. Duplex Sequencing reduces the error rate of NGS such that a single nucleotide mutation can be detected in >1×10
7
wild-type nucleotides.
Duplex Sequencing (DS) is a next-generation sequencing methodology capable of detecting a sin...
Alternative Titles
Full title
Detecting ultralow-frequency mutations by Duplex Sequencing
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4271547
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4271547
Other Identifiers
ISSN
1754-2189
E-ISSN
1750-2799
DOI
10.1038/nprot.2014.170
