Autologous aldrithiol-2-inactivated HIV-1 combined with polyinosinic-polycytidylic acid–poly- l -lys...
Autologous aldrithiol-2-inactivated HIV-1 combined with polyinosinic-polycytidylic acid–poly- l -lysine carboxymethylcellulose as a vaccine platform for therapeutic dendritic cell immunotherapy
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Publisher
Netherlands: Elsevier Ltd
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Language
English
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Publisher
Netherlands: Elsevier Ltd
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Contents
Highlights • Autologous AT-2 inactivated HIV can be derived from donor CD4+ T cells for use a DC vaccine immunogen. • This immunogen can be generated in GMP laboratories without highly specialized equipment. • AT-2 HIV-pulsed DCs matured with Poly-ICLC secrete IL-12 and induce HIV-specific immunity. • This formulation is now approved for investigat...
Alternative Titles
Full title
Autologous aldrithiol-2-inactivated HIV-1 combined with polyinosinic-polycytidylic acid–poly- l -lysine carboxymethylcellulose as a vaccine platform for therapeutic dendritic cell immunotherapy
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4272884
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4272884
Other Identifiers
ISSN
0264-410X,1873-2518
E-ISSN
1873-2518
DOI
10.1016/j.vaccine.2014.10.054
