Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
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Author / Creator
Fontebasso, Adam M , Papillon-Cavanagh, Simon , Schwartzentruber, Jeremy , Nikbakht, Hamid , Gerges, Noha , Fiset, Pierre-Olivier , Bechet, Denise , Faury, Damien , De Jay, Nicolas , Ramkissoon, Lori A , Corcoran, Aoife , Jones, David T W , Sturm, Dominik , Johann, Pascal , Tomita, Tadanori , Goldman, Stewart , Nagib, Mahmoud , Bendel, Anne , Goumnerova, Liliana , Bowers, Daniel C , Leonard, Jeffrey R , Rubin, Joshua B , Alden, Tord , Browd, Samuel , Geyer, J Russell , Leary, Sarah , Jallo, George , Cohen, Kenneth , Gupta, Nalin , Prados, Michael D , Carret, Anne-Sophie , Ellezam, Benjamin , Crevier, Louis , Klekner, Almos , Bognar, Laszlo , Hauser, Peter , Garami, Miklos , Myseros, John , Dong, Zhifeng , Siegel, Peter M , Malkin, Hayley , Ligon, Azra H , Albrecht, Steffen , Pfister, Stefan M , Ligon, Keith L , Majewski, Jacek , Jabado, Nada and Kieran, Mark W
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Nada Jabado and colleagues report identification of gain-of-function mutations in
ACVR1
, which encodes activin A receptor type I, in midline pediatric high-grade astrocytomas.
Pediatric midline high-grade astrocytomas (mHGAs) are incurable with few treatment targets identified. Most tumors harbor mutations encoding p.Lys27Met in histone H...
Alternative Titles
Full title
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
Authors, Artists and Contributors
Author / Creator
Papillon-Cavanagh, Simon
Schwartzentruber, Jeremy
Nikbakht, Hamid
Gerges, Noha
Fiset, Pierre-Olivier
Bechet, Denise
Faury, Damien
De Jay, Nicolas
Ramkissoon, Lori A
Corcoran, Aoife
Jones, David T W
Sturm, Dominik
Johann, Pascal
Tomita, Tadanori
Goldman, Stewart
Nagib, Mahmoud
Bendel, Anne
Goumnerova, Liliana
Bowers, Daniel C
Leonard, Jeffrey R
Rubin, Joshua B
Alden, Tord
Browd, Samuel
Geyer, J Russell
Leary, Sarah
Jallo, George
Cohen, Kenneth
Gupta, Nalin
Prados, Michael D
Carret, Anne-Sophie
Ellezam, Benjamin
Crevier, Louis
Klekner, Almos
Bognar, Laszlo
Hauser, Peter
Garami, Miklos
Myseros, John
Dong, Zhifeng
Siegel, Peter M
Malkin, Hayley
Ligon, Azra H
Albrecht, Steffen
Pfister, Stefan M
Ligon, Keith L
Majewski, Jacek
Jabado, Nada
Kieran, Mark W
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4282994
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4282994
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.2950
