Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning...
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents
About this item
Full title
Author / Creator
Griebel, Guy , Pichat, Philippe , Beeské, Sandra , Leroy, Thibaud , Redon, Nicolas , Jacquet, Agnès , Françon, Dominique , Bert, Lionel , Even, Luc , Lopez-Grancha, Mati , Tolstykh, Tatiana , Sun, Fangxian , Yu, Qunyan , Brittain, Scott , Arlt, Heike , He, Timothy , Zhang, Bailin , Wiederschain, Dmitri , Bertrand, Thomas , Houtmann, Jacques , Rak, Alexey , Vallée, François , Michot, Nadine , Augé, Franck , Menet, Véronique , Bergis, Olivier E. , George, Pascal , Avenet, Patrick , Mikol, Vincent , Didier, Michel and Escoubet, Johanna
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Monoacylglycerol lipase (MAGL) represents a primary degradation enzyme of the endogenous cannabinoid (eCB), 2-arachidonoyglycerol (2-AG). This study reports a potent covalent MAGL inhibitor, SAR127303. The compound behaves as a selective and competitive inhibitor of mouse and human MAGL, which potently elevates hippocampal levels of 2-AG in mice.
Alternative Titles
Full title
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents
Authors, Artists and Contributors
Author / Creator
Pichat, Philippe
Beeské, Sandra
Leroy, Thibaud
Redon, Nicolas
Jacquet, Agnès
Françon, Dominique
Bert, Lionel
Even, Luc
Lopez-Grancha, Mati
Tolstykh, Tatiana
Sun, Fangxian
Yu, Qunyan
Brittain, Scott
Arlt, Heike
He, Timothy
Zhang, Bailin
Wiederschain, Dmitri
Bertrand, Thomas
Houtmann, Jacques
Rak, Alexey
Vallée, François
Michot, Nadine
Augé, Franck
Menet, Véronique
Bergis, Olivier E.
George, Pascal
Avenet, Patrick
Mikol, Vincent
Didier, Michel
Escoubet, Johanna
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4284516
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4284516
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep07642
