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CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

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CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4297519

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

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London: Nature Publishing Group UK

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Scope and Contents

Contents

CEACAM1 functions as a novel heterophilic ligand for TIM-3 and is necessary for TIM-3-mediated tolerance, which has marked consequences for inflammation, infection and cancer.
Interaction of CEACAM1 and TIM-3
T cell regulation is mediated by a number of inhibitory cell surface molecules such as T-cell immunoglobulin domain and mucin domain-3...

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Full title

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4297519

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4297519

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature13848

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