An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Blocking ERK/MAP kinases improves insulin sensitivity thorough a mechanism similar to the actions of the anti-diabetic thiazolidinediones drugs on PPARγ.
Role of MEK/ERK pathway in glucose metabolism
The nuclear receptor PPARγ is required for glucose metabolism and is a drug target in diabetes. Earlier work has suggested that PPARγ phosphoryl...
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Full title
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4297557
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4297557
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature13887
