Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The growth of tumours is supported by tumour production of lactic acid, which polarizes tumour-associated macrophages to an M2 phenotype through a pathway dependent on hypoxia-inducible factor 1α.
The making of tumour-associated macrophages
Tumour-associated macrophages (TAMs) are thought to promote tumorigenesis through a variety of mechanis...
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Full title
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4301845
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4301845
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature13490
