Tumour suppressor TRIM33 targets nuclear β-catenin degradation
Tumour suppressor TRIM33 targets nuclear β-catenin degradation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Aberrant activation of β-catenin in the nucleus has been implicated in a variety of human cancers, but the fate of nuclear β-catenin is unknown. Here we demonstrate that the tripartite motif-containing protein 33 (TRIM33), acting as an E3 ubiquitin ligase, reduces the abundance of nuclear β-catenin protein. TRIM33-mediated β-catenin is destabilized...
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Full title
Tumour suppressor TRIM33 targets nuclear β-catenin degradation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4315364
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4315364
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms7156
