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Endothelial destabilization by angiopoietin-2 via integrin β1 activation

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Endothelial destabilization by angiopoietin-2 via integrin β1 activation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4316742

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

About this item

Full title

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Author / Creator

Hakanpaa, Laura , Sipila, Tuomas , Leppanen, Veli-Matti , Gautam, Prson , Nurmi, Harri , Jacquemet, Guillaume , Eklund, Lauri , Ivaska, Johanna , Alitalo, Kari and Saharinen, Pipsa

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2015-01, Vol.6 (1), p.5962-5962, Article 5962

Language

English

Formats

Articles

Publication information

Publisher

London: Nature Publishing Group UK

Subjects

More information

Scope and Contents

Contents

Angiopoietins regulate vascular homeostasis via the endothelial Tie receptor tyrosine kinases. Angiopoietin-1 (Ang1) supports endothelial stabilization via Tie2 activation. Angiopoietin-2 (Ang2) functions as a context-dependent Tie2 agonist/antagonist promoting pathological angiogenesis, vascular permeability and inflammation. Elucidating Ang2-depe...

Alternative Titles

Full title

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Authors, Artists and Contributors

Author / Creator

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Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4316742

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4316742

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/ncomms6962

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