Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
About this item
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Author / Creator
Fang, Sungsoon , Suh, Jae Myoung , Reilly, Shannon M , Yu, Elizabeth , Osborn, Olivia , Lackey, Denise , Yoshihara, Eiji , Perino, Alessia , Jacinto, Sandra , Lukasheva, Yelizaveta , Atkins, Annette R , Khvat, Alexander , Schnabl, Bernd , Yu, Ruth T , Brenner, David A , Coulter, Sally , Liddle, Christopher , Schoonjans, Kristina , Olefsky, Jerrold M , Saltiel, Alan R , Downes, Michael and Evans, Ronald M
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Restriction of FXR agonism to the gut improves obesity and diabetes.
The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy, bile acid release during a m...
Alternative Titles
Full title
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Authors, Artists and Contributors
Author / Creator
Suh, Jae Myoung
Reilly, Shannon M
Yu, Elizabeth
Osborn, Olivia
Lackey, Denise
Yoshihara, Eiji
Perino, Alessia
Jacinto, Sandra
Lukasheva, Yelizaveta
Atkins, Annette R
Khvat, Alexander
Schnabl, Bernd
Yu, Ruth T
Brenner, David A
Coulter, Sally
Liddle, Christopher
Schoonjans, Kristina
Olefsky, Jerrold M
Saltiel, Alan R
Downes, Michael
Evans, Ronald M
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4320010
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4320010
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3760
