Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
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Australian Ovarian Cancer Management Group , Ghoussaini, Maya , Edwards, Stacey L. , Hillman, Kristine M. , Kaufmann, Susanne , Beesley, Jonathan , Dennis, Joe , Bolla, Manjeet K. , Dicks, Ed , Guo, Qi , Schmidt, Marjanka K. , Shah, Mitul , Luben, Robert , Darabi, Hatef , Eriksson, Mikael , Bojesen, Stig E. , Nordestgaard, Børge G. , Lambrechts, Diether , Neven, Patrick , Wildiers, Hans , Th Rutgers, Emiel J. , Couch, Fergus J. , Hallberg, Emily , Vachon, Celine , Seibold, Petra , Flesch-Janys, Dieter , dos-Santos-Silva, Isabel , Gibson, Lorna , Nevanlinna, Heli , Aittomäki, Kristiina , Blomqvist, Carl , Hall, Per , Kang, Daehee , Park, Sue K. , Iwata, Hiroji , Truong, Thérèse , Menegaux, Florence , Burwinkel, Barbara , Marme, Frederik , Sohn, Christof , Tseng, Chiu-chen , Van Den Berg, David , Stram, Daniel O. , Perez, Jose Ignacio Arias , Shu, Xiao-Ou , Cai, Qiuyin , Reed, Malcolm W. R. , Tchatchou, Sandrine , Sawyer, Elinor J. , Kerin, Michael J. , Henderson, Brian E. , YIP, Cheng Har , Wong, Tien Y. , Martens, John W. M. , Hopper, John L. , Tsimiklis, Helen , Kapuscinski, Miroslav K. , Shen, Chen-Yang , Giles, Graham G. , Hartman, Mikael , Haeberle, Lothar , Ekici, Arif B. , Ashworth, Alan , García-Closas, Montserrat , Lissowska, Jolanta , Simard, Jacques , Goldberg, Mark S. , Labrèche, France , Dumont, Martine , Pylkäs, Katri , Jukkola-Vuorinen, Arja , Brauch, Hiltrud , Brüning, Thomas , Radice, Paolo , Volorio, Sara , Helbig, Sonja , Mannermaa, Arto , Kataja, Vesa , Tollenaar, Robert A. E. M. , Seynaeve, Caroline , Jaworska-Bieniek, Katarzyna , Toland, Amanda E. , Ambrosone, Christine B. , Yannoukakos, Drakoulis , Sangrajrang, Suleeporn , McKay, James , Long, Jirong , Anton-Culver, Hoda , Neuhausen, Susan L. , Baynes, Caroline , Ahmed, Shahana , Maranian, Mel , González-Neira, Anna , Herrero, Daniel , Vincent, Daniel , Carroll, Jason , Caldas, Carlos , Brown, Melissa A. , Lupien, Mathieu , Kristensen, Vessela N. and Easton, Douglas F.
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the ‘iCOGS’ genotyping array and impute genotypes for a further 1,284 using 1000 Genomes Project data. All but two, strongly correlated SNPs (rs444...
Alternative Titles
Full title
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Authors, Artists and Contributors
Author / Creator
Ghoussaini, Maya
Edwards, Stacey L.
Hillman, Kristine M.
Kaufmann, Susanne
Beesley, Jonathan
Dennis, Joe
Bolla, Manjeet K.
Dicks, Ed
Guo, Qi
Schmidt, Marjanka K.
Shah, Mitul
Luben, Robert
Darabi, Hatef
Eriksson, Mikael
Bojesen, Stig E.
Nordestgaard, Børge G.
Lambrechts, Diether
Neven, Patrick
Wildiers, Hans
Th Rutgers, Emiel J.
Couch, Fergus J.
Hallberg, Emily
Vachon, Celine
Seibold, Petra
Flesch-Janys, Dieter
dos-Santos-Silva, Isabel
Gibson, Lorna
Nevanlinna, Heli
Aittomäki, Kristiina
Blomqvist, Carl
Hall, Per
Kang, Daehee
Park, Sue K.
Iwata, Hiroji
Truong, Thérèse
Menegaux, Florence
Burwinkel, Barbara
Marme, Frederik
Sohn, Christof
Tseng, Chiu-chen
Van Den Berg, David
Stram, Daniel O.
Perez, Jose Ignacio Arias
Shu, Xiao-Ou
Cai, Qiuyin
Reed, Malcolm W. R.
Tchatchou, Sandrine
Sawyer, Elinor J.
Kerin, Michael J.
Henderson, Brian E.
YIP, Cheng Har
Wong, Tien Y.
Martens, John W. M.
Hopper, John L.
Tsimiklis, Helen
Kapuscinski, Miroslav K.
Shen, Chen-Yang
Giles, Graham G.
Hartman, Mikael
Haeberle, Lothar
Ekici, Arif B.
Ashworth, Alan
García-Closas, Montserrat
Lissowska, Jolanta
Simard, Jacques
Goldberg, Mark S.
Labrèche, France
Dumont, Martine
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Brauch, Hiltrud
Brüning, Thomas
Radice, Paolo
Volorio, Sara
Helbig, Sonja
Mannermaa, Arto
Kataja, Vesa
Tollenaar, Robert A. E. M.
Seynaeve, Caroline
Jaworska-Bieniek, Katarzyna
Toland, Amanda E.
Ambrosone, Christine B.
Yannoukakos, Drakoulis
Sangrajrang, Suleeporn
McKay, James
Long, Jirong
Anton-Culver, Hoda
Neuhausen, Susan L.
Baynes, Caroline
Ahmed, Shahana
Maranian, Mel
González-Neira, Anna
Herrero, Daniel
Vincent, Daniel
Carroll, Jason
Caldas, Carlos
Brown, Melissa A.
Lupien, Mathieu
Kristensen, Vessela N.
Easton, Douglas F.
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4321900
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4321900
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms5999
