Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextrometh...
Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells
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Author / Creator
Xiao, Wen-jing , Ma, Ting , Ge, Chun , Xia, Wen-juan , Mao, Yong , Sun, Run-bin , Yu, Xiao-yi , Aa, Ji-ye and Wang, Guang-ji
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Aim： The pentose phosphate pathway （PPP） is involved in the activity of glucose-6-phosphate dehydrogenase （G6PD） and generation of NADPH, which plays a key role in drug metabolism. The aim of this study was to investigate the effects of modulation of the PPP on drug metabolism capacity in vitro. Methods： A pair of hepatic cell lines, ie the cancero...
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Full title
Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4326794
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4326794
Other Identifiers
ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/aps.2014.137
