Genetic and epigenetic fine mapping of causal autoimmune disease variants
Genetic and epigenetic fine mapping of causal autoimmune disease variants
About this item
Full title
Author / Creator
Farh, Kyle Kai-How , Marson, Alexander , Zhu, Jiang , Kleinewietfeld, Markus , Housley, William J. , Beik, Samantha , Shoresh, Noam , Whitton, Holly , Ryan, Russell J. H. , Shishkin, Alexander A. , Hatan, Meital , Carrasco-Alfonso, Marlene J. , Mayer, Dita , Luckey, C. John , Patsopoulos, Nikolaos A. , De Jager, Philip L. , Kuchroo, Vijay K. , Epstein, Charles B. , Daly, Mark J. , Hafler, David A. and Bernstein, Bradley E.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-mapping algorithm to identify candidate causal variants for 21 autoimmune diseases from genotyping data. We integrated these predictions with transcription and
cis
-r...
Alternative Titles
Full title
Genetic and epigenetic fine mapping of causal autoimmune disease variants
Authors, Artists and Contributors
Author / Creator
Marson, Alexander
Zhu, Jiang
Kleinewietfeld, Markus
Housley, William J.
Beik, Samantha
Shoresh, Noam
Whitton, Holly
Ryan, Russell J. H.
Shishkin, Alexander A.
Hatan, Meital
Carrasco-Alfonso, Marlene J.
Mayer, Dita
Luckey, C. John
Patsopoulos, Nikolaos A.
De Jager, Philip L.
Kuchroo, Vijay K.
Epstein, Charles B.
Daly, Mark J.
Hafler, David A.
Bernstein, Bradley E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4336207
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4336207
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/nature13835
