Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexi...
Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study
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Author / Creator
for the LAPLACE-TIMI 57 Investigators , LAPLACE-TIMI 57 Investigators , Giugliano, Robert P, Dr , Desai, Nihar R, MD , Kohli, Payal, MD , Rogers, William J, Prof , Somaratne, Ransi, MD , Huang, Fannie, MS , Liu, Thomas, PhD , Mohanavelu, Satishkumar, MS , Hoffman, Elaine B, PhD , McDonald, Shannon T, BSN , Abrahamsen, Timothy E, BA , Wasserman, Scott M, MD , Scott, Robert, MD and Sabatine, Marc S, MD
Publisher
Kidlington: Elsevier Ltd
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Language
English
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Publisher
Kidlington: Elsevier Ltd
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Contents
Summary Background LDL cholesterol (LDL-C) is a well established risk factor for cardiovascular disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds LDL receptors, targeting them for degradation. We therefore assessed the efficacy, safety, and tolerability of AMG 145, a human monoclonal IgG2 antibody against PCSK9, in stable patient...
Alternative Titles
Full title
Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study
Authors, Artists and Contributors
Author / Creator
LAPLACE-TIMI 57 Investigators
Giugliano, Robert P, Dr
Desai, Nihar R, MD
Kohli, Payal, MD
Rogers, William J, Prof
Somaratne, Ransi, MD
Huang, Fannie, MS
Liu, Thomas, PhD
Mohanavelu, Satishkumar, MS
Hoffman, Elaine B, PhD
McDonald, Shannon T, BSN
Abrahamsen, Timothy E, BA
Wasserman, Scott M, MD
Scott, Robert, MD
Sabatine, Marc S, MD
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4347805
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4347805
Other Identifiers
ISSN
0140-6736
E-ISSN
1474-547X
DOI
10.1016/S0140-6736(12)61770-X
