Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the UPS, in which Ub-conjugated substrates are deubiquitinated, unfolded and cleaved into small peptides when pas...
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Full title
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4351408
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4351408
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ISSN
2092-6413,1226-3613
E-ISSN
2092-6413
DOI
10.1038/emm.2014.117
