Phase I study of AEE788, a novel multitarget inhibitor of ErbB- and VEGF-receptor-family tyrosine ki...
Phase I study of AEE788, a novel multitarget inhibitor of ErbB- and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients
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Publisher
Berlin/Heidelberg: Springer-Verlag
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Springer-Verlag
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Purpose
Vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) play a significant role in glioblastoma angiogenesis and proliferation, making tyrosine kinase (TK) receptors logical targets for treatment. We evaluated AEE788, a reversible TK inhibitor that inhibits EGFR and VEGFR, in recurrent glioblastoma...
Alternative Titles
Full title
Phase I study of AEE788, a novel multitarget inhibitor of ErbB- and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4351868
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4351868
Other Identifiers
ISSN
0344-5704,1432-0843
E-ISSN
1432-0843
DOI
10.1007/s00280-012-1854-6
