Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In
Caenorhabditis elegans
, reduced insulin/IGF-1 signalling can promote longevity through a program that is genetically distinct from the dauer developmental pathway, and requires SKN-1-dependent collagen remodelling that is a broadly essential feature of longevity assurance pathways.
Increased collagen production linked to longevity
I...
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Full title
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4352135
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4352135
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14021
