Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes
Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Cytokeratin19 (KRT19) is widely used as a biomarker for the detection of disseminated tumors. Using an LC-MS/MS proteomics approach, we found that KRT19 was upregulated in HER2-overexpressing cells and tissues. KRT19 expression was induced by HER2-downstream ERK at the transcriptional level. Another HER2-downstream kinase, Akt, was found to phospho...
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Full title
Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4356337
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4356337
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2014.155
