The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogene...
The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Aberrant cholesterol homeostasis and biosynthesis has been observed in different tumour types. This paper investigates the role of the post-squalenic enzyme of cholesterol biosynthesis, oxidosqualene cyclase (OSC), in regulating tumour angiogenesis and metastasis dissemination in mouse models of cancer. We showed that Ro 48-8071, a selective inhibi...
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Full title
The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4357009
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4357009
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep09054
