Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and...
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity
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Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Aggregation and aggregation-mediated formation of toxic alpha synuclein (aSyn) species have been linked to the pathogenesis of sporadic and monogenic Parkinson's disease (PD). A novel H50Q mutation of aSyn, resulting in the substitution of histidine by glutamine, has recently been identified in PD patients. We have previously shown that the lipid p...
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Full title
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4365527
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4365527
Other Identifiers
ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-015-0004-0
