Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mi...
Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
PIKfyve is essential for the synthesis of phosphatidylinositol-3,5-bisphosphate [PtdIns(3,5)P
2
] and for the regulation of endolysosomal membrane dynamics in mammals. PtdIns(3,5)P
2
deficiency causes neurodegeneration in mice and humans, but the role of PtdIns(3,5)P
2
in non-neural tissues is poorly understood. Here we show that...
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Full title
Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4369914
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4369914
Other Identifiers
E-ISSN
2041-1723
DOI
10.1038/ncomms5691
