hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1
hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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A method, termed hiCLIP, has been developed to determine the RNA duplexes bound by RNA-binding proteins, revealing an unforeseen prevalence of long-range duplexes in 3′ untranslated regions (UTRs), and a decreased incidence of SNPs in duplex-forming regions; the results also show that RNA structure is able to regulate gene expression.
Probing na...
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hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4376666
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4376666
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14280
