TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy
TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy
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Author / Creator
Hu, Zheng , Ding, Wencheng , Zhu, Da , Yu, Lan , Jiang, Xiaohui , Wang, Xiaoli , Zhang, Changlin , Wang, Liming , Ji, Teng , Liu, Dan , He, Dan , Xia, Xi , Zhu, Tao , Wei, Juncheng , Wu, Peng , Wang, Changyu , Xi, Ling , Gao, Qinglei , Chen, Gang , Liu, Rong , Li, Kezhen , Li, Shuang , Wang, Shixuan , Zhou, Jianfeng , Ma, Ding and Wang, Hui
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Persistent HPV infection is recognized as the main etiologic factor for cervical cancer. HPV expresses the oncoproteins E6 and E7, both of which play key roles in maintaining viral infection and promoting carcinogenesis. While siRNA-mediated targeting of E6 and E7 transcripts temporarily induces apoptosis in HPV-positive cells, it does not eliminat...
Alternative Titles
Full title
TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy
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Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4382249
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4382249
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI78206
