Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine oxidase (XO), the oxidized form of xanthine dehydr...
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Full title
Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4382995
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4382995
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms7555
