PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Key Points
Oncogenic mutation of the phosphatidylinositol 3-kinase (PI3K) catalytic isoform p110α is frequent in human cancers, whereas the catalytic isoforms p110β, p110δ and p110γ are rarely mutated but can be overexpressed. Mutation or loss of expression of regulatory isoform p85α is also associated with cancer.
Although class IA PI3K cata...
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Full title
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4384662
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4384662
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ISSN
1474-175X
E-ISSN
1474-1768
DOI
10.1038/nrc3860
