A draft map of the human proteome
A draft map of the human proteome
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Kim, Min-Sik , Pinto, Sneha M. , Getnet, Derese , Nirujogi, Raja Sekhar , Manda, Srikanth S. , Chaerkady, Raghothama , Madugundu, Anil K. , Kelkar, Dhanashree S. , Isserlin, Ruth , Jain, Shobhit , Thomas, Joji K. , Muthusamy, Babylakshmi , Leal-Rojas, Pamela , Kumar, Praveen , Sahasrabuddhe, Nandini A. , Balakrishnan, Lavanya , Advani, Jayshree , George, Bijesh , Renuse, Santosh , Selvan, Lakshmi Dhevi N. , Patil, Arun H. , Nanjappa, Vishalakshi , Radhakrishnan, Aneesha , Prasad, Samarjeet , Subbannayya, Tejaswini , Raju, Rajesh , Kumar, Manish , Sreenivasamurthy, Sreelakshmi K. , Marimuthu, Arivusudar , Sathe, Gajanan J. , Chavan, Sandip , Datta, Keshava K. , Subbannayya, Yashwanth , Sahu, Apeksha , Yelamanchi, Soujanya D. , Jayaram, Savita , Rajagopalan, Pavithra , Sharma, Jyoti , Murthy, Krishna R. , Syed, Nazia , Goel, Renu , Khan, Aafaque A. , Ahmad, Sartaj , Dey, Gourav , Mudgal, Keshav , Chatterjee, Aditi , Huang, Tai-Chung , Zhong, Jun , Wu, Xinyan , Shaw, Patrick G. , Freed, Donald , Zahari, Muhammad S. , Mukherjee, Kanchan K. , Shankar, Subramanian , Mahadevan, Anita , Lam, Henry , Mitchell, Christopher J. , Shankar, Susarla Krishna , Satishchandra, Parthasarathy , Schroeder, John T. , Sirdeshmukh, Ravi , Maitra, Anirban , Leach, Steven D. , Drake, Charles G. , Halushka, Marc K. , Prasad, T. S. Keshava , Hruban, Ralph H. , Kerr, Candace L. , Bader, Gary D. , Iacobuzio-Donahue, Christine A. , Gowda, Harsha and Pandey, Akhilesh
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted in identification of proteins encoded by 17,294 genes accounting for approximately 84% of the total annotated protein-coding genes in humans. A unique and comprehensive strategy for proteogenomic analysis enabled us to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-coding RNAs and upstream open reading frames. This large human proteome catalogue (available as an interactive web-based resource at
http://www.humanproteomemap.org
) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease.
A draft map of the human proteome is presented here, accounting for over 80% of the annotated protein-coding genes in humans; some novel protein-coding regions, including translated pseudogenes, non-coding RNAs and ups...
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Full title
A draft map of the human proteome
Authors, Artists and Contributors
Author / Creator
Pinto, Sneha M.
Getnet, Derese
Nirujogi, Raja Sekhar
Manda, Srikanth S.
Chaerkady, Raghothama
Madugundu, Anil K.
Kelkar, Dhanashree S.
Isserlin, Ruth
Jain, Shobhit
Thomas, Joji K.
Muthusamy, Babylakshmi
Leal-Rojas, Pamela
Kumar, Praveen
Sahasrabuddhe, Nandini A.
Balakrishnan, Lavanya
Advani, Jayshree
George, Bijesh
Renuse, Santosh
Selvan, Lakshmi Dhevi N.
Patil, Arun H.
Nanjappa, Vishalakshi
Radhakrishnan, Aneesha
Prasad, Samarjeet
Subbannayya, Tejaswini
Raju, Rajesh
Kumar, Manish
Sreenivasamurthy, Sreelakshmi K.
Marimuthu, Arivusudar
Sathe, Gajanan J.
Chavan, Sandip
Datta, Keshava K.
Subbannayya, Yashwanth
Sahu, Apeksha
Yelamanchi, Soujanya D.
Jayaram, Savita
Rajagopalan, Pavithra
Sharma, Jyoti
Murthy, Krishna R.
Syed, Nazia
Goel, Renu
Khan, Aafaque A.
Ahmad, Sartaj
Dey, Gourav
Mudgal, Keshav
Chatterjee, Aditi
Huang, Tai-Chung
Zhong, Jun
Wu, Xinyan
Shaw, Patrick G.
Freed, Donald
Zahari, Muhammad S.
Mukherjee, Kanchan K.
Shankar, Subramanian
Mahadevan, Anita
Lam, Henry
Mitchell, Christopher J.
Shankar, Susarla Krishna
Satishchandra, Parthasarathy
Schroeder, John T.
Sirdeshmukh, Ravi
Maitra, Anirban
Leach, Steven D.
Drake, Charles G.
Halushka, Marc K.
Prasad, T. S. Keshava
Hruban, Ralph H.
Kerr, Candace L.
Bader, Gary D.
Iacobuzio-Donahue, Christine A.
Gowda, Harsha
Pandey, Akhilesh
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4403737
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4403737
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature13302
