Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
IDH1 and IDH2 mutations sensitize acute myeloid leukemia cells to the BCL-2 inhibitor ABT-199.
Mutant isocitrate dehydrogenase (IDH) 1 and 2 proteins alter the epigenetic landscape in acute myeloid leukemia (AML) cells through production of the oncometabolite (
R
)-2-hydroxyglutarate (2-HG). Here we performed a large-scale RNA interference...
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Full title
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4406275
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4406275
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3788
