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DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4410389

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

About this item

Full title

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2015-04, Vol.6 (1), p.6910-6910, Article 6910

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Mammary stem/progenitor cells (MaSCs) maintain self-renewal of the mammary epithelium during puberty and pregnancy. DNA methylation provides a potential epigenetic mechanism for maintaining cellular memory during self-renewal. Although DNA methyltransferases (DNMTs) are dispensable for embryonic stem cell maintenance, their role in maintaining MaSC...

Alternative Titles

Full title

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4410389

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4410389

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/ncomms7910

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