Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
About this item
Full title
Author / Creator
Schoors, Sandra , Bruning, Ulrike , Missiaen, Rindert , Queiroz, Karla C. S. , Borgers, Gitte , Elia, Ilaria , Zecchin, Annalisa , Cantelmo, Anna Rita , Christen, Stefan , Goveia, Jermaine , Heggermont, Ward , Goddé, Lucica , Vinckier, Stefan , Van Veldhoven, Paul P. , Eelen, Guy , Schoonjans, Luc , Gerhardt, Holger , Dewerchin, Mieke , Baes, Myriam , De Bock, Katrien , Ghesquière, Bart , Lunt, Sophia Y. , Fendt, Sarah-Maria and Carmeliet, Peter
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The metabolism of endothelial cells during vessel sprouting remains poorly studied. Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not migration, of human and murine endothelial cells. Reduction of FAO in endothelial cells did not...
Alternative Titles
Full title
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Authors, Artists and Contributors
Author / Creator
Bruning, Ulrike
Missiaen, Rindert
Queiroz, Karla C. S.
Borgers, Gitte
Elia, Ilaria
Zecchin, Annalisa
Cantelmo, Anna Rita
Christen, Stefan
Goveia, Jermaine
Heggermont, Ward
Goddé, Lucica
Vinckier, Stefan
Van Veldhoven, Paul P.
Eelen, Guy
Schoonjans, Luc
Gerhardt, Holger
Dewerchin, Mieke
Baes, Myriam
De Bock, Katrien
Ghesquière, Bart
Lunt, Sophia Y.
Fendt, Sarah-Maria
Carmeliet, Peter
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4413024
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4413024
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14362
