Inhibition of an NAD+ Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent...
Inhibition of an NAD+ Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent Stem Cells
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Publisher
Durham, NC, USA: AlphaMed Press
Journal title
Language
English
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Publisher
Durham, NC, USA: AlphaMed Press
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Contents
The tumorigenic potential of human pluripotent stem cells (hPSCs) is a major limitation to the widespread use of hPSC derivatives in the clinic. Here, we demonstrate that the small molecule STF‐31 is effective at eliminating undifferentiated hPSCs across a broad range of cell culture conditions with important advantages over previously described me...
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Full title
Inhibition of an NAD+ Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent Stem Cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4414215
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4414215
Other Identifiers
ISSN
2157-6564
E-ISSN
2157-6580
DOI
10.5966/sctm.2014-0163
