Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
About this item
Full title
Author / Creator
Liao, Jing , Karnik, Rahul , Gu, Hongcang , Ziller, Michael J , Clement, Kendell , Tsankov, Alexander M , Akopian, Veronika , Gifford, Casey A , Donaghey, Julie , Galonska, Christina , Pop, Ramona , Reyon, Deepak , Tsai, Shengdar Q , Mallard, William , Joung, J Keith , Rinn, John L , Gnirke, Andreas and Meissner, Alexander
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Alexander Meissner and colleagues use CRISPR/Cas9 genome editing to inactivate the DNA methyltransferases
DNMT1
,
DNMT3A
and
DNMT3B
in human embryonic stem cells (ESCs). They find an essential role for DNMT1 in human ESCs and generate genome-wide maps of the DNA methylation changes that occur following inactivation of these enzyme...
Alternative Titles
Full title
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4414868
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4414868
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3258
