TP53 loss creates therapeutic vulnerability in colorectal cancer
TP53 loss creates therapeutic vulnerability in colorectal cancer
About this item
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Genomic deletion of the tumour suppressor
TP53
frequently includes other neighbouring genes, such as the
POLR2A
housekeeping gene that encodes a crucial RNA polymerase II subunit; suppression of POLR2A with α-amanitin or by RNA interference selectively inhibits the tumorigenic potential of cancer cells, and in mouse models of cancer, tu...
Alternative Titles
Full title
TP53 loss creates therapeutic vulnerability in colorectal cancer
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4417759
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4417759
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14418
