Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
About this item
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Author / Creator
Fischer, Eric S. , Böhm, Kerstin , Lydeard, John R. , Yang, Haidi , Stadler, Michael B. , Cavadini, Simone , Nagel, Jane , Serluca, Fabrizio , Acker, Vincent , Lingaraju, Gondichatnahalli M. , Tichkule, Ritesh B. , Schebesta, Michael , Forrester, William C. , Schirle, Markus , Hassiepen, Ulrich , Ottl, Johannes , Hild, Marc , Beckwith, Rohan E. J. , Harper, J. Wade , Jenkins, Jeremy L. and Thomä, Nicolas H.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
In the 1950s, the drug thalidomide, administered as a sedative to pregnant women, led to the birth of thousands of children with multiple defects. Despite the teratogenicity of thalidomide and its derivatives lenalidomide and pomalidomide, these immunomodulatory drugs (IMiDs) recently emerged as effective treatments for multiple myeloma and 5q-dele...
Alternative Titles
Full title
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
Authors, Artists and Contributors
Author / Creator
Böhm, Kerstin
Lydeard, John R.
Yang, Haidi
Stadler, Michael B.
Cavadini, Simone
Nagel, Jane
Serluca, Fabrizio
Acker, Vincent
Lingaraju, Gondichatnahalli M.
Tichkule, Ritesh B.
Schebesta, Michael
Forrester, William C.
Schirle, Markus
Hassiepen, Ulrich
Ottl, Johannes
Hild, Marc
Beckwith, Rohan E. J.
Harper, J. Wade
Jenkins, Jeremy L.
Thomä, Nicolas H.
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4423819
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4423819
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature13527
