Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Gianpietro Dotti and colleagues report that CAR-T cells expressing heparanase to degrade the extracellular matrix may enhance their infiltration of and effects on solid tumors.
Adoptive transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less striking therapeutic effects in solid tumors
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Full title
Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4425589
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4425589
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3833
