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Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4425589

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

About this item

Full title

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Publisher

New York: Nature Publishing Group US

Journal title

Nature medicine, 2015-05, Vol.21 (5), p.524-529

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Gianpietro Dotti and colleagues report that CAR-T cells expressing heparanase to degrade the extracellular matrix may enhance their infiltration of and effects on solid tumors.
Adoptive transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less striking therapeutic effects in solid tumors
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Alternative Titles

Full title

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4425589

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4425589

Other Identifiers

ISSN

1078-8956

E-ISSN

1546-170X

DOI

10.1038/nm.3833

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