Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast ca...
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
About this item
Full title
Author / Creator
Wei, Shuo , Kozono, Shingo , Kats, Lev , Nechama, Morris , Li, Wenzong , Guarnerio, Jlenia , Luo, Manli , You, Mi-Hyeon , Yao, Yandan , Kondo, Asami , Hu, Hai , Bozkurt, Gunes , Moerke, Nathan J , Cao, Shugeng , Reschke, Markus , Chen, Chun-Hau , Rego, Eduardo M , Lo-Coco, Francesco , Cantley, Lewis C , Lee, Tae Ho , Wu, Hao , Zhang, Yan , Pandolfi, Pier Paolo , Zhou, Xiao Zhen and Lu, Kun Ping
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
All-
trans
retinoic acid binds to, inhibits and induces degradation of the active form of the prolyl isomerase Pin1, thereby turning off and on a variety of Pin1 substrate oncogenes and tumor suppressors, respectively.
A common key regulator of oncogenic signaling pathways in multiple tumor types is the unique isomerase Pin1. However, avai...
Alternative Titles
Full title
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
Authors, Artists and Contributors
Author / Creator
Kozono, Shingo
Kats, Lev
Nechama, Morris
Li, Wenzong
Guarnerio, Jlenia
Luo, Manli
You, Mi-Hyeon
Yao, Yandan
Kondo, Asami
Hu, Hai
Bozkurt, Gunes
Moerke, Nathan J
Cao, Shugeng
Reschke, Markus
Chen, Chun-Hau
Rego, Eduardo M
Lo-Coco, Francesco
Cantley, Lewis C
Lee, Tae Ho
Wu, Hao
Zhang, Yan
Pandolfi, Pier Paolo
Zhou, Xiao Zhen
Lu, Kun Ping
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4425616
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4425616
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3839
