First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and...
First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity
About this item
Full title
Author / Creator
Zeh, Herbert J , Downs-Canner, Stephanie , McCart, J Andrea , Guo, Zong Sheng , Rao, Uma N M , Ramalingam, Lekshmi , Thorne, Stephen H , Jones, Heather L , Kalinski, Pawel , Wieckowski, Eva , O'Malley, Mark E , Daneshmand, Manijeh , Hu, Kang , Bell, John C , Hwang, Tae-Ho , Moon, Anne , Breitbach, Caroline J , Kirn, David H and Bartlett, David L
Publisher
United States: Elsevier Inc
Journal title
Language
English
Formats
Publication information
Publisher
United States: Elsevier Inc
Subjects
More information
Scope and Contents
Contents
Oncolytic viral therapy utilizes a tumor-selective replicating virus which preferentially infects and destroys cancer cells and triggers antitumor immunity. The Western Reserve strain of vaccinia virus (VV) is the most virulent strain of VV in animal models and has been engineered for tumor selectivity through two targeted gene deletions (vvDD). We...
Alternative Titles
Full title
First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity
Authors, Artists and Contributors
Author / Creator
Downs-Canner, Stephanie
McCart, J Andrea
Guo, Zong Sheng
Rao, Uma N M
Ramalingam, Lekshmi
Thorne, Stephen H
Jones, Heather L
Kalinski, Pawel
Wieckowski, Eva
O'Malley, Mark E
Daneshmand, Manijeh
Hu, Kang
Bell, John C
Hwang, Tae-Ho
Moon, Anne
Breitbach, Caroline J
Kirn, David H
Bartlett, David L
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4426804
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4426804
Other Identifiers
ISSN
1525-0016
E-ISSN
1525-0024
DOI
10.1038/mt.2014.194
