Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target
Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target
About this item
Full title
Author / Creator
Publisher
Washington: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
Washington: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
In prokaryotes, RNA derived from type I and type III CRISPR loci direct large ribonucleoprotein complexes to destroy invading bacteriophage and plasmids. In Escherichia coli, this 405-kilodalton complex is called Cascade. We report the crystal structure of Cascade bound to a single-stranded DNA (ssDNA) target at a resolution of 3.03 angstroms. The...
Alternative Titles
Full title
Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4427192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4427192
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1256996
