Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of co...
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
About this item
Full title
Author / Creator
Cowley, Glenn S , Weir, Barbara A , Vazquez, Francisca , Tamayo, Pablo , Scott, Justine A , Rusin, Scott , East-Seletsky, Alexandra , Ali, Levi D , Gerath, William FJ , Pantel, Sarah E , Lizotte, Patrick H , Jiang, Guozhi , Hsiao, Jessica , Tsherniak, Aviad , Dwinell, Elizabeth , Aoyama, Simon , Okamoto, Michael , Harrington, William , Gelfand, Ellen , Green, Thomas M , Tomko, Mark J , Gopal, Shuba , Wong, Terence C , Li, Hubo , Howell, Sara , Stransky, Nicolas , Liefeld, Ted , Jang, Dongkeun , Bistline, Jonathan , Hill Meyers, Barbara , Armstrong, Scott A , Anderson, Ken C , Stegmaier, Kimberly , Reich, Michael , Pellman, David , Boehm, Jesse S , Mesirov, Jill P , Golub, Todd R , Root, David E and Hahn, William C
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Using a genome-scale, lentivirally delivered shRNA library, we performed massively parallel pooled shRNA screens in 216 cancer cell lines to identify genes that are required for cell proliferation and/or viability. Cell line dependencies on 11,000 genes were interrogated by 5 shRNAs per gene. The proliferation effect of each shRNA in each cell line...
Alternative Titles
Full title
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Authors, Artists and Contributors
Author / Creator
Weir, Barbara A
Vazquez, Francisca
Tamayo, Pablo
Scott, Justine A
Rusin, Scott
East-Seletsky, Alexandra
Ali, Levi D
Gerath, William FJ
Pantel, Sarah E
Lizotte, Patrick H
Jiang, Guozhi
Hsiao, Jessica
Tsherniak, Aviad
Dwinell, Elizabeth
Aoyama, Simon
Okamoto, Michael
Harrington, William
Gelfand, Ellen
Green, Thomas M
Tomko, Mark J
Gopal, Shuba
Wong, Terence C
Li, Hubo
Howell, Sara
Stransky, Nicolas
Liefeld, Ted
Jang, Dongkeun
Bistline, Jonathan
Hill Meyers, Barbara
Armstrong, Scott A
Anderson, Ken C
Stegmaier, Kimberly
Reich, Michael
Pellman, David
Boehm, Jesse S
Mesirov, Jill P
Golub, Todd R
Root, David E
Hahn, William C
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4432652
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4432652
Other Identifiers
ISSN
2052-4463
E-ISSN
2052-4463
DOI
10.1038/sdata.2014.35
