Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
About this item
Full title
Author / Creator
Ko, Sung-Youl , Pegu, Amarendra , Rudicell, Rebecca S. , Yang, Zhi-yong , Joyce, M. Gordon , Chen, Xuejun , Wang, Keyun , Bao, Saran , Kraemer, Thomas D. , Rath, Timo , Zeng, Ming , Schmidt, Stephen D. , Todd, John-Paul , Penzak, Scott R. , Saunders, Kevin O. , Nason, Martha C. , Haase, Ashley T. , Rao, Srinivas S. , Blumberg, Richard S. , Mascola, John R. and Nabel, Gary J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A mutation in VRC01, a broadly neutralizing, HIV-1-specific antibody, confers enhanced binding to the neonatal Fc receptor, increasing the antibody half-life in the serum and localization in mucosal tissues, where it provides superior protection against rectal simian HIV-1 infection in macaques.
Enhanced anti-HIV activity in mutant VRC01 antibod...
Alternative Titles
Full title
Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
Authors, Artists and Contributors
Author / Creator
Pegu, Amarendra
Rudicell, Rebecca S.
Yang, Zhi-yong
Joyce, M. Gordon
Chen, Xuejun
Wang, Keyun
Bao, Saran
Kraemer, Thomas D.
Rath, Timo
Zeng, Ming
Schmidt, Stephen D.
Todd, John-Paul
Penzak, Scott R.
Saunders, Kevin O.
Nason, Martha C.
Haase, Ashley T.
Rao, Srinivas S.
Blumberg, Richard S.
Mascola, John R.
Nabel, Gary J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4433741
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4433741
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature13612
