SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infilt...
SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model
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Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
TGF-β signaling plays critical roles in the pathogenesis of aneurysms; however, it is still unclear whether its role is protective or destructive. In this study, we investigate the role of SMAD3 in the pathogenesis of calcium chloride (CaCl
2
)-induced abdominal aortic aneurysms (AAA) in
Smad3
−/−
,
Smad3
+/−
and
Smad3
Alternative Titles
Full title
SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4434993
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4434993
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep10180
