Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosen...
Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Significance Cytoplasmic dynein is the primary minus-end–directed microtubule (MT) motor. It is unclear how dynein coordinates ATP hydrolysis and MT attachment within and between its two motor domains, each containing four AAA+ ATPases (AAA: ATPase associated with various cellular activities), AAA1–4. We characterize how mechanical tension and nucl...
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Full title
Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4443381
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4443381
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1417422112
