Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and pr...
Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
About this item
Full title
Author / Creator
Leiserson, Mark D M , Vandin, Fabio , Wu, Hsin-Ta , Dobson, Jason R , Eldridge, Jonathan V , Thomas, Jacob L , Papoutsaki, Alexandra , Kim, Younhun , Niu, Beifang , McLellan, Michael , Lawrence, Michael S , Gonzalez-Perez, Abel , Tamborero, David , Cheng, Yuwei , Ryslik, Gregory A , Lopez-Bigas, Nuria , Getz, Gad , Ding, Li and Raphael, Benjamin J
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Benjamin Raphael and colleagues report an analysis of altered subnetworks of somatic aberrations in TCGA pan-cancer data sets, including 3,281 samples from 12 cancer types, using a newly developed HotNet2 algorithm. They identify 16 significantly mutated subnetworks and provide a more comprehensive view into altered pathways, including those with k...
Alternative Titles
Full title
Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes
Authors, Artists and Contributors
Author / Creator
Vandin, Fabio
Wu, Hsin-Ta
Dobson, Jason R
Eldridge, Jonathan V
Thomas, Jacob L
Papoutsaki, Alexandra
Kim, Younhun
Niu, Beifang
McLellan, Michael
Lawrence, Michael S
Gonzalez-Perez, Abel
Tamborero, David
Cheng, Yuwei
Ryslik, Gregory A
Lopez-Bigas, Nuria
Getz, Gad
Ding, Li
Raphael, Benjamin J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4444046
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4444046
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3168
