Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
About this item
Full title
Author / Creator
McLellan, Jason S. , Chen, Man , Joyce, M. Gordon , Sastry, Mallika , Stewart-Jones, Guillaume B. E. , Yang, Yongping , Zhang, Baoshan , Chen, Lei , Srivatsan, Sanjay , Zheng, Anqi , Zhou, Tongqing , Graepel, Kevin W. , Kumar, Azad , Moin, Syed , Boyington, Jeffrey C. , Chuang, Gwo-Yu , Soto, Cinque , Baxa, Ulrich , Bakker, Arjen Q. , Spits, Hergen , Beaumont, Tim , Zheng, Zizheng , Xia, Ningshao , Ko, Sung-Youl , Todd, John-Paul , Rao, Srinivas , Graham, Barney S. and Kwong, Peter D.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Respiratory syncytial virus (RSV) is the leading cause of hospitalisation for children under 5 years of age. We sought to engineer a viral antigen that provides greater protection than currently available vaccines and focused on antigenic site φ, a metastable site specific to the prefusion state of the RSV fusion (F) glycoprotein, as this site is t...
Alternative Titles
Full title
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
Authors, Artists and Contributors
Author / Creator
Chen, Man
Joyce, M. Gordon
Sastry, Mallika
Stewart-Jones, Guillaume B. E.
Yang, Yongping
Zhang, Baoshan
Chen, Lei
Srivatsan, Sanjay
Zheng, Anqi
Zhou, Tongqing
Graepel, Kevin W.
Kumar, Azad
Moin, Syed
Boyington, Jeffrey C.
Chuang, Gwo-Yu
Soto, Cinque
Baxa, Ulrich
Bakker, Arjen Q.
Spits, Hergen
Beaumont, Tim
Zheng, Zizheng
Xia, Ningshao
Ko, Sung-Youl
Todd, John-Paul
Rao, Srinivas
Graham, Barney S.
Kwong, Peter D.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4461862
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4461862
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1243283
