Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogen...
Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells
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Author / Creator
Kotini, Andriana G , Chang, Chan-Jung , Boussaad, Ibrahim , Delrow, Jeffrey J , Dolezal, Emily K , Nagulapally, Abhinav B , Perna, Fabiana , Fishbein, Gregory A , Klimek, Virginia M , Hawkins, R David , Huangfu, Danwei , Murry, Charles E , Graubert, Timothy , Nimer, Stephen D and Papapetrou, Eirini P
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Cellular reprogramming is used to pinpoint the genetic abnormalities in a blood cancer caused by a large chromosomal deletion.
Chromosomal deletions associated with human diseases, such as cancer, are common, but synteny issues complicate modeling of these deletions in mice. We use cellular reprogramming and genome engineering to functionally di...
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Full title
Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4464949
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4464949
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.3178
